Xiao Tang Kong, M.D.

Xiao Tang Kong, M.D.

Associate Clinical Professor, Neurology

Biography

Dr. Kong is an associate clinical professor of Neurology and a board-certified UCI Health neuro-oncologist who specializes in the diagnosis and non-surgical treatment of primary brain tumors, metastatic cancers of brain and spinal cord, as well as neurological complications from tumors/cancers and their therapies such as radiation therapy, chemotherapy, immunotherapy as well as targeted therapy. Dr. Kong earned her medical degree from the Keck School of Medicine at USC. She completed an internship in internal medicine and a residency in neurology at UC Irvine Medical Center, followed by a fellowship in neuro-oncology at the David Geffen School of Medicine at UCLA. She also received her doctoral degrees from the University of Tokyo, Japan and Capital University of Medical Science in Beijing, China. Dr. Kong is deeply involved in managing clinical trials for brain and spinal cord tumors.

Research in Lay Terms

Dr. Kong’s goal is to bring safe and effective clinical trials to treat patients with brain and spinal cord tumors, to advance research activities in the field of glioblastoma, rare brain tumors, CNS lymphoma as well as metastatic cancers to brain.

Publications

Kong XT, Fu D, Carrillo J, and Bota D. Assessing the beneficial impacts of the neuro-oncology hospitalist model: A pilot run at UC Irvine. Neuro Oncology 2016;18 (suppl 6): vi160-vi161.

Kong XT, Alexandru D and Bota D. Epidemiology of Central Nervous System Metastases. In: Brain Metastases from Primary Tumors. Edited by Hayat MA, Elsevier, 2014:11-24.

Clayton E, Madamba J, Kong, XT and Braskett M. Successful desensitization protocol for delayed cutaneuous eruption to temozolomide. The Journal of Allergy and Clinical Immunology: In Practice. 2(3) March/April, 2014 http://dx.doi.org/10.1016/j.jaip.2014.03.016

Lisheng Ge, Neil T. Hoa, Zechariah Wilson, Gabriel Arismendi-Morillo, Xiao-Tang Kong, Rajeev B. Tajhya, Christine Beeton, and Martin R. Jadus. Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy. J of International Immunopharmacology. 22 (2): 427-443, 2014

Hardy A, Prins R, Kong XT, Woodworth D, Pope W, Yong W, Cloughesy T, Liau L, and Elingson B. Enhancing tumor response using quatitative volumetry from T1 suntraction maps in malignant glioma treated with dentritic cell vaccination. Neuro Oncology 2014 Nov; 16 (Suppl 5): v 145. doi: 10.1093/neuonc/nou264.30

Xiao-Tang Kong, Stacey Green, Emese Filka, Richard Green, William Yong, Phioanh Nghiemphu, Timothy Cloughesy, Albert Lai. Phase II pilot study of VELCADE® (Bortezomib) in combination with Temozolomide and regional radiation therapy for upfront treatment of patients with newly-diagnosed glioblastoma multiforme. Neuro-Oncology 15:iii75–iii84, 2013. doi:10.1093/neuonc/not179

Xiao-Tang Kong, Tom Davidson, Albert Lai, Timothy Cloughesy, Phioanh (Leia) Nghiemphu. Long term follow up after the treatment of adult intracranial or intraspinal primary pure germinoma. Neuro-Oncology 15:iii98–iii135, 2013. doi:10.1093/neuonc/not182

Fu DB, Alexandru D, Curticiu D, Kong XT and Bota D. The use of intravitreal rituximab in conjunction with systemic temozolomide and intravenous rituximab for the treatment of primary intraocular lymphoma. Hematology and Leukemia 2013. http://www.hoajonline.com/journals/pdf/2052-434X-1-1.pdf

Beverly Dan Fu, Xiao-Tang Kong and Daniela Bota. A case report of chemotherapy alone for the treatment of primary CNS T-cell lymphoma. Neuro-Oncology 14:vi65–vi85, 2012. doi:10.1093/neuonc/nos229

Kong XT, Gao H and Stanbridge EJ. Mechanism of differential activation of target gene promoters by p53 hinge domain mutants with impaired apoptotic function. J Biol Chem. 276(35): 32990-33000, 2001.

Kong XT, Choi SH, Bessho F, Kobayashi M, Hanada R Yamamoto K and Hayashi Y. Codon 201Gly polymorphism type of the DCC gene is related to the disseminated neuroblastoma. Neoplasia, 3(4): 267-272, 2001.

Choi SH, Kong XT, Taki T, Tsuchida Y, Kawaguchi H, Kato H, Hanada R, Look AT and Hayashi Y. Reduced or absent expression and codon 201 polymorphism of DCC gene in rhabdomyosarcoma and Ewing’s sarcoma/PNET family. Int J Mol Med, 6: 463-467, 2000.

Aurelio ON, Kong XT, Gupta S, and Stanbridge EJ. p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines. Mol. Cell. Biol. 20(3): 770-778, 2000.

Kong XT, Valentine VA, Rowe ST, Valentine MB, Ragsdale ST, Jones BG, Wilkinson DA, Brodeur GM, Cohn SL and Look AT. Lack of Homozygous inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines. Neoplasia, 1(1): 80-89, 1999.

Kong XT, Choi SH, Inoue A, Takita J, Yokota J, Hanada R, Yamamoto K, Bessho F, Yanagisawa M, Hayashi Y. Alterations of the tumour suppressor gene DCC in neuroblastoma. Eur J Cancer, 33(12): 1962-1965, 1997.

Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M and Hayashi Y. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood, 90(3): 1192-1199, 1997.

Kong XT, Choi SH, Inoue A, Xu F, Chen T, Takita J, Yokota J, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, and Hayashi Y. Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. Cancer Res., 57(17): 3772-3778, 1997.

Kong XT, Choi SH, Takita J, Yokota J, Hanada R, Yamamoto K, Bessho F, Yanagisawa M, Hayashi Y. Alterations of the tumor suppressor gene DCC in Childhood solid tumors. J Jpn Pediatr Society (Japanese), 101: 1492-1498, 1997.

Kong XT, Zhaori GT, Wang GZ and Jiang ZF. Treatment of acute lower respiratory tract infection in children caused by respiratory syncytial virus with inhalation of aerosolized Shuanghuanglian. Chin J Pediatr (Chinese), 34 (1): 11-14, 1996.

Kong XT and Jiang ZF. Current status on ribavirin aerosol treatment of respiratory syncytial virus infection in children in the world (review). Chin J Pediatr (Chinese) 131(2): 119 -121, 1993.

Kong XT, Fang HT, Jiang GQ, Zhai SZ, O' Connell DL and Brewster DR. Treatment of acute bronchiolitis with Chinese herbs. Arch Dis Child (England), 68(4): 468-471, 1993.

Kong XT, Zhaori GT, Wang GZ and Jiang ZF. Inhibition of Shanghuanglian on RSV in vitro and its antiviral mechanism. J Shuanghuanglian (Chinese) 2(1): 1-5, 1992.

Kong XT and Fang HT. Clinical analysis of 110 children with lower respiratory infection due to RSV in Harbin area. J Clin Pediatric (Chinese) 9(5): 299-301, 1991.

Kong XT and Fang HT. Rapid diagnosis of RSV infection by MACEIA. J Harbin Med Univ (Chinese) 23(3): 172-174, 1989.