SCRC

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Specialist Series FY 20-21
JPF #06139

Specialist positions are occasionally available throughout the year in the Sue and Bill Gross Stem Cell Research Center at the University of California, Irvine. These are typically grant‐funded positions under the sponsorship of various faculty members (http://stemcell.uci.edu/people/).

Qualified candidates with a B.S/B.A., M.S., or Ph.D., degree should send a cover letter and curriculum vitae along with the names and addresses of three references to the following on‐line recruitment URL: https://recruit.ap.uci.edu/apply/JPF06139

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

Professional Researcher Series FY 21-22
JPF# 06976

Researcher Series positions are occasionally available throughout the year in the Sue and Bill Gross Stem Cell Research Center at the University of California, Irvine. Applications are sought from candidates with Ph. D or M.D. degree with a strong laboratory research background, publications, and specialized training in biochemistry, biophysics, molecular biology, or related fields. This is an ongoing recruitment. Positions are dependent on extramural funding. Rank will be determined based on qualifications and experience. Initial appointments are for one year and renewal will be dependent on the availability of support. Salary commensurate with qualifications and experience.

Please apply at: https://recruit.ap.uci.edu/JPF06976

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin,  disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

 

Project Scientist Series FY 21-22
JPF# 06977

Project Scientist positions are occasionally available throughout the year in the Sue and Bill Gross Stem Cell Research Center at the University of California, Irvine. These are typically grant-funded positions under the sponsorship of various faculty members http://stemcell.uci.edu/people/).

Qualified candidates with a Ph.D., degree or its equivalent should send a cover letter and curriculum vitae along with the names and addresses of three references to the following on-line recruitment URL: https://recruit.ap.uci.edu/apply/JPF06977

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

 

Postdoctoral Scholar FY 20-21
JPF# 06215

Postdoctoral positions are occasionally available throughout the year in the Sue and Bill Gross Stem Cell Research Center at the University of California, Irvine. These are typically grant-funded positions under the sponsorship of various faculty members (http://stemcell.uci.edu/people/).

Qualified candidates with MD or PhD degree should send a cover letter and curriculum vitae along with the names and addresses of three references to the following on-line recruitment URL:
https://recruit.ap.uci.edu/apply/JPF06215

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

 

CRISPR/Cas9 Gene Editing Core Facility Manager
JPF# 06990

The successful applicant will fill the role of CRISPR/Cas9 Gene Editing Core Facility Manager within the UCI Sue & Bill Gross Stem Cell Research Center.
This is a new position with the primary responsibility of establishing a new gene editing core facility. The appointed individual will be responsible for development and implementation of standard operating procedures in performance of all aspects of in vitro gene editing in a variety of human stem cells including embryonic, adult, and induced pluripotent stem cells. The manager will consult with anticipated users in the development of their grant proposals and projects, assist users in design and execution of gene editing protocols for a variety of applications, as well as provide guidance and advice in selection, expansion and validation of gene edited stem cell cultures as needed by a wide variety of users and investigators.
Managing the gene editing core includes training and assisting researchers on and off campus in principles and techniques of in vitro gene editing, as well as developing innovative new approaches and protocols to solve complex research problems. The manager will work with SCRC leadership and administrative staff to establish and expand the operations of the gene editing core recharge facility, including establishing appropriate recharge rates for budget office approval, report preparation, assistance with all aspects of booking, monitoring usage, billing and reconciliation.

Major Responsibilities
1)Research (75% Effort)
The core manager will serve to enable and expand the use of in vitro gene editing capabilities across a wide variety of faculty members’ research programs. The manager will consult with individual faculty members and their research team members to advise and assist in the design and planning of experimental approaches to make maximum use of the available capabilities of the core facility. The manager is expected to provide solutions for stem cell, regenerative medicine, cell biology, biochemistry, immunology and cancer research utilizing the latest developments in today’s rapidly changing technical environment. The manager will provide detailed input into experimental data analysis and interpretation, contributing to manuscript preparation and peer-reviewed publications. As well, the manager will provide advice, guidance and content concerning use of gene editing for grant proposal submissions. The manager is expected to be a co-author of scientific publications and recognized for academic achievements through multiple research grants, fellowship awards and scholarships.

2)Professional Competence and Activity (15% Effort)
In order to maximize the use and utility of the facility, the manager is expected to be a regional and national leader in the use of gene editing approaches to enable a variety of research programs. The manager will participate in and lead professional development and training activities, meetings, seminars, professional and technical societies, as well as other research and educational organizations to establish and maintain the SCRC facility as a leader in gene editing. The manager will also provide input and guidance as needed for the preparation and review of grant proposals, manuscripts, presentations and other publications that include use of the facility and resources. 3) University and Public Service (10% Effort)The manager will serve to promote the SCRC facility and the appropriate use of gene editing technologies within UCI and throughout an external network of interested individuals. The manager will be a competent teacher, providing training to a variety of researchers, including undergraduate students, graduate students, postdoctoral fellows, faculty members and stem cell techniques course participants, in appropriate and innovative research use of gene editing capabilities and technologies. The manager is expected to participate as a leader in local and regional organizations that facilitate and promote innovative development and use of gene editing techniques in research.

Qualifications
The successful applicant will have at least a Master’s degree (PhD is preferred) or a minimum of five years of experience in stem cell culture and gene editing techniques, including expertise in using and editing iPSC or ESC models of human disease. The manager will be highly knowledgeable in all aspects of CRISPR/Cas9 and other gene editing technologies and their application to stem cell and regenerative medicine research, as well as having high levels of competence in experimental design, analysis and interpretation.

Assistant rank Ms or 5 yrs experience
Associate rank Ms or 5-10 yrs experience
Specialist rank Terminal degree (PhD/MD) or 10+ yrs experience

Application procedure: Applicants should submit an application, curriculum vitae, and a minimum of 2-5 references at https://recruit.ap.uci.edu/apply/JPF06990

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. A recipient of an NSF ADVANCE award for gender equity, UCI is responsive to the needs of dual career couples, supports work‐life balance through an array of family‐friendly policies, and is dedicated to broadening participation in higher education.

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Postdoctoral positions available in the Center for Complex Biological Systems, University of California, Irvine, California, USA

Two fully-funded positions are available for postdoctoral scholars interested in using mouse molecular genetics, genomics, and computational models to understand fundamental problems in nervous system and heart development and morphogenesis.

One project focuses on the polygenic basis of congenital heart defects and the transcriptional identity of heart progenitor cells in mouse models of mammalian heart development.  Research for the heart project will be focused on understanding how multiple small perturbations to gene expression act collectively to produce heart defects in multi-system birth defects disorders known as transcriptomopathies.

The second project exploits mathematical modeling and genetically-engineered mice to discover how the sizes of neural tissues are precisely specified in the face of developmental variability and external perturbations. Experimental work will focus on transient stem/progenitor cell ablations and their effects on development of neural structures.  Experimental data will be used to validate models of strategies for tissue size control. This work is of direct relevance to the etiology of microcephaly and other neural birth defects.

Successful applicants will have a Ph.D. in molecular and/or developmental biology, neurobiology, genetics, or genomics, and evidence of publication and/or preparation of high quality journal article(s). Successful applicants will have training that provides sufficient preparation for them to be able to use mouse genetics, embryology, molecular biology, high resolution optical imaging (including optical projection tomography and magnetic resolution imaging), together with genomics (RNA sequencing/bioinformatics) to identify morphogenetic abnormalities (progenitor cell proliferation, patterning and migration) and gene expression changes. Single-cell RNA sequencing of early mouse embryos will be used to identify relevant transcriptional changes in individual progenitor cells.

The salary ranges for these positions are negotiable and will be commensurate with training and experience; healthcare benefits are included. Appointments will initially be for a one-year period with extensions for up to 3 years, subject to performance.

Requirements:

  • Curriculum Vitae – Your most recently updated C.V.
  • Cover Letter including Statement of Research
  • References: 2-3 letters of reference required

Please send inquiries to:

Anne L. Calof, Professor, CCBS (alcalof@uci.edu)

Arthur D. Lander, Professor and Director, CCBS (adlander@uci.edu)

 

 

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Postdoctoral position available to study stem cells in congenital heart disease

The UC Irvine Center for Complex Biological Systems (http://ccbs.uci.edu) seeks one to two postdoctoral scholars to study the polygenic basis of congenital heart defects, and the transcriptional identity of heart stem/progenitor cells, in mouse models of mammalian heart development.  The positions are  fully funded and will be supervised by Professors Anne Calof and Arthur Lander.  Research will focus on how multiple small perturbations to gene expression collectively produce heart defects in multi-system birth defects disorders known as transcriptomopathies.

The successful applicant will have a Ph.D. in molecular and/or developmental biology, genetics, or genomics, and evidence of publication and/or preparation of high quality journal article(s). The applicant’s training should provide sufficient preparation to use mouse genetics, embryology, molecular biology, high resolution imaging (including optical projection tomography and MRI), together with genomics (RNA sequencing/bioinformatics), to identify morphogenetic abnormalities (progenitor cell proliferation, patterning and migration) and gene expression changes. Single-cell RNA sequencing of early embryos will also be used to identify transcriptional changes in individual progenitor cells.

Salary level is negotiable and will depend upon the candidate’s experience. All appointments are for one year with potential for extension for up to 3 yeaars dependent upon performance and funding.

Requirements

Please submit a letter of interest, current CV, statement of research and a minimum of 2 reference letters to:
https://recruit.ap.uci.edu/apply/JPF04213

 

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

 

 

Research Scientist, Neurology

Location: UC Irvine

Schedule: Full-time

Description

Summary/Scope

The Research Scientist, Neurology will have a strong background and publication record in cellular or molecular biology of cancer, with a preference for expertise in proteasome biology.  The applicant will be able to design and execute a variety of routine in vitro functional assays such as proliferation and gene expression pathway analysis in the context of mechanisms of resistance to chemotherapy.  In addition, the applicant will also be working with in vivo models to understand the biological role of this pathway in various cancer indications. The successful candidate will have the opportunity to work closely with discovery and development scientists from both academia and industry, and to present his or her work at project team meetings.

 

Responsibilities will include, but are not limited to, the following:

  • Plan and execute experiments independently
  • Stay current with the literature in order to design experiments that address biological questions
  • Analyze, interpret and present scientific data
  • Interact with drug development team members to design experiments that can address mechanistic questions for the therapeutic of interest
  • Accurately maintain data and reports

 

Qualifications

PhD in Pharmacology, Molecular Biology, or a related biological discipline.  Expertise in design and execution of cell-based biological studies is required.  Experience with rodent model development to characterize anti-cancer activity in vivo, including execution of preclinical pharmacology studies, is required.  Experience with grant writing and submission, managing internal and externally conducted studies, and monitoring study conduct and reporting are highly desired.  Industry experience is preferred but not essential.

 

Skills/Knowledge Required

  • Solid understanding of oncology discovery research, focused primarily on in vitro and in vivo evaluation of small molecules targeting oncology disease targets.
  • Ability to generate high quality data in a dynamic fast paced environment.
  • Excellent written and verbal communication skills
  • Experience in in vivo study conduct; animal handling, husbandry, dosing by multiple routes, observation recording, blood, tissue collection and limited necropsy.
  • Knowledge of in vitro assessment of pharmacologic activity.
  • Knowledge of outsourcing CROs and monitoring of studies at outsourced sites.

Qualified candidates can contact Dr. Daniela Bota, dbota@uci.edu, for additional information and application procedures.

 

Postdoctoral position available to Study Heart Stem Cells and the Polygenic Basis of Congenital Heart Defects

The UC Irvine Center for Complex Biological Systems (http://ccbs.uci.edu) seeks a postdoctoral scholar to study the polygenic basis of congenital heart defects, and the transcriptional identity of heart progenitor cells, in mouse models of mammalian heart development.  The position is fully funded and will be supervised by Professors Anne Calof and Arthur Lander.  Research will focus on how multiple small perturbations to gene expression collectively produce heart defects in multi-system birth defects disorders known as transcriptomopathies.

The successful applicant will have a Ph.D. in molecular and/or developmental biology, genetics, or genomics, and evidence of publication and/or preparation of high quality journal article(s). The applicant’s training should provide sufficient preparation to use mouse genetics, embryology, molecular biology, high resolution imaging (including optical projection tomography and MRI), together with genomics (RNA sequencing/bioinformatics), to identify morphogenetic abnormalities (progenitor cell proliferation, patterning and migration) and gene expression changes. Single-cell RNA sequencing of early embryos will also be used to identify transcriptional changes in individual progenitor cells.

Salary level is negotiable and will depend upon the candidate’s experience. All appointments are for one year with potential for extension dependent upon performance and funding.

Requirements

Please submit a letter of interest, current CV, statement of research and a minimum of 2 reference letters to:
https://recruit.ap.uci.edu/apply/JPF04213

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.